Keratin-Butyrate Scaffolds Promote Skin Wound Healing in Diabetic Rats Through Down-Regulation of IL-1? and Up-Regulation of Keratins 16 and 17

Impaired wound healing particularly in diabetics creates a significant healthcare burden. The study aimed to evaluate the effect of keratin-butyrate fibers (FKDP +0.1%NaBu) full-thickness skin model 30 diabetic rats. Physicochemical examination showed that obtained dressing possesses heterogeneous structure and butyrate was slowly released into wound. Moreover, is nontoxic supports cell growth. In vivo results accelerated on days 4 7 post-injury (p < .05). Histopathological immunofluorescence revealed applied stimulated macrophage infiltration, which favors tissue remodeling regeneration. naturally incorporated regenerating tissue. highest mRNA expression level interleukin 1? (IL-1?) observed during first 2 weeks control wounds compared FKDP +0.1%NaBu treated wounds, IL-1? significantly decreased. dressed IL-10 VEGF increased .05) from day 14. Keratin-butyrate enhanced keratin 16 17 zonula occludens protein-1 junctional adhesion molecules 14, 21, 28 post-injuries. Our safe can efficiently accelerate